Fourth daughter of Ferdinand and Isabella of Spain, and wife of Henry VIII., her brother-in-law as widow of Arthur, from whom, and at whose instance, after 18 years of married life, and after giving birth to five children, she was divorced on the plea that, as she had been his brother's wife before, it was not lawful for him to have her; after her divorce she remained in the country, led an austere religious life, and died broken-hearted. The refusal of the Pope to sanction this divorce led to the final rupture of the English Church from the Church of Rome, and the emancipation of the nation from priestly tyranny (1483-1536).