1). Any technique that manipulates living organisms (or parts of organisms) to make or modify products, to improve plants or animals, or to develop microorganisms for specific uses. An applied biological science--e.g., recombinant DNA technology. 2). The various industrial processes that involve the use of biological systems; the collection of microbial and other biochemical processes carried out on an industrial scale. It includes, but is not limited to, the industrial aspects of genetic engineering. Other areas of biotechnology deal with fermentation technology (antibiotics), hybridoma technology (monoclonal antibodies), and agricultural technology (plant and animal transformation).